BimEL antibody (N-Term)
Reactivity: Rat, Human, Mouse
WB, ELISA, ICC, IF
Host: Rabbit
Polyclonal
unconjugated
-
- Target See all BimEL products
- BimEL
- Binding Specificity
- AA 20-70, N-Term
- Reactivity
- Rat, Human, Mouse
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This BimEL antibody is un-conjugated
- Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- Bim EL antibody is human and mouse reactive. Multiple isoforms of Bim are known to exist, this antibody only detects the Bim EL isoform.
- Purification
- Bim EL Antibody is affinity chromatography purified via peptide column.
- Immunogen
- Bim EL antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Bim. The immunogen is located within amino acids 20 - 70 of Bim EL.
- Isotype
- IgG
-
-
- Application Notes
-
Bim EL antibody can be used for detection of Bim EL by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Bim EL Antibody is supplied in PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,4 °C
- Storage Comment
- Bim EL antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
-
- Target
- BimEL
- Alternative Name
- Bim EL (BimEL Products)
- Background
- Bim EL Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim, also known as Bcl-2-like protein 11, is a pro-apoptotic member of this family and interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Multiple isoforms of Bim are known to exist, with Bim EL being the longest isoform (1,2).
- Molecular Weight
-
Predicted: 22 kDa
Observed: 24 kDa - Gene ID
- 10018
- NCBI Accession
- NP_619527
- UniProt
- O43521
-
You are here:
