ANKRD15 antibody (N-Term)

Catalog No. ABIN6991851

Product Details anti-ANKRD15 Antibody

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANKRD15 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Two alternatively spliced transcript variants encoding different isoforms have been identified. The lower molecular weight band seen in the immunoblot is thought to be non-specific.

Purification: KANK1 Antibody is affinity chromatography purified via peptide column.

Immunogen: KANK1 antibody was raised against a 19 amino acid peptide near the amino terminus of human KANK1 . The immunogen is located within the first 50 amino acids of KANK1.

Isotype: IgG

Application Details

Application Notes: KANK1 Antibody can be used for detection of KANK1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KANK1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KANK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ANKRD15

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Alternative Name: KANK1 (ANKRD15 Products)

Background: KANK1 Antibody: Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK1 (KN motif and ankyrin repeat domain-containing protein 1), also known as ANKRD15, is a 1,352 amino acid protein that contains at least 12 exons and 5 ANK repeats. It binds to beta-catenin and regulates its subcellular distribution. KANK1 is ubiquitously expressed and localizes to cytoplasm. It may function as a tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder.

Molecular Weight: Predicted: 149 kDa

Observed: 150 kDa

Gene ID: 23189

NCBI Accession: NP_055973

UniProt: Q14678

Pathways: Regulation of Actin Filament Polymerization