ANKRD15 antibody (N-Term)

Catalog No. ABIN6991851

Product Details anti-ANKRD15 Antibody

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANKRD15 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Two alternatively spliced transcript variants encoding different isoforms have been identified. The lower molecular weight band seen in the immunoblot is thought to be non-specific.

Purification: KANK1 Antibody is affinity chromatography purified via peptide column.

Immunogen: KANK1 antibody was raised against a 19 amino acid peptide near the amino terminus of human KANK1 . The immunogen is located within the first 50 amino acids of KANK1.

Isotype: IgG

Application Details

Application Notes: KANK1 Antibody can be used for detection of KANK1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KANK1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KANK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ANKRD15

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Alternative Name: KANK1 (ANKRD15 Products)

Synonyms: ANKRD15 antibody, CPSQ2 antibody, KANK antibody, A930031B09Rik antibody, AU015049 antibody, AW121052 antibody, Ankrd15 antibody, D330024H06Rik antibody, mKIAA0172 antibody, KANK1 antibody, ankrd15 antibody, kank1.2 antibody, DMRT1 antibody, KN motif and ankyrin repeat domains 1 antibody, KN motif and ankyrin repeat domains 1 L homeolog antibody, doublesex and mab-3 related transcription factor 1 antibody, KANK1 antibody, Kank1 antibody, kank1.L antibody, DMRT1 antibody

Background: KANK1 Antibody: Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK1 (KN motif and ankyrin repeat domain-containing protein 1), also known as ANKRD15, is a 1,352 amino acid protein that contains at least 12 exons and 5 ANK repeats. It binds to beta-catenin and regulates its subcellular distribution. KANK1 is ubiquitously expressed and localizes to cytoplasm. It may function as a tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder.

Molecular Weight: Predicted: 149 kDa

Observed: 150 kDa

Gene ID: 23189

NCBI Accession: NP_055973

UniProt: Q14678

Pathways: Regulation of Actin Filament Polymerization