RRAS2 antibody (C-Term)

Catalog No. ABIN6991827

Product Details anti-RRAS2 Antibody

Target: RRAS2 (Related RAS Viral (R-Ras) Oncogene Homolog 2 (RRAS2))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRAS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Two isoforms of RRAS2 exists as a result of alternative splicing event.

Purification: RRAS2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal RRAS2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human RRAS2. The immunogen is located within the last 50 amino acids of RRAS2.

Isotype: IgG

Application Details

Application Notes: RRAS2 antibody can be used for detection of RRAS2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: RRAS2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: RRAS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for RRAS2

Target: RRAS2 (Related RAS Viral (R-Ras) Oncogene Homolog 2 (RRAS2))

Alternative Name: RRAS2 (RRAS2 Products)

Synonyms: TC21 antibody, 2610016H24Rik antibody, C86394 antibody, Ras-related protein R-Ras2 antibody, RAS related 2 antibody, related RAS viral (r-ras) oncogene 2 antibody, related RAS viral (r-ras) oncogene homolog 2 antibody, TVAG_453070 antibody, Bm1_46660 antibody, RRAS2 antibody, Rras2 antibody

Background: RRAS2 Antibody: Activating mutations and overexpression of classical Ras subfamily members (K-RAS, N-RAS and H-RAS) have been widely investigated as key events in the development of human cancers. The RRAS subfamily of Ras-related proteins includes RRAS1, RRAS2 (TC21) and RRAS3 (M-Ras) show overall amino acid identity with the classical Ras subfamily (H-Ras, K-Ras and N-Ras) of 55-60 % . RRAS2 is a small GTPbinding protein of the Ras superfamily of GTPases. It might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins. RRAS2 has high oncogenic potential and overexpression/mutations have been reported in several tumor tissues and cell lines.

Molecular Weight: 22 kDa

Gene ID: 22800

NCBI Accession: NP_036382

UniProt: P62070