ATG2B antibody (N-Term)

Catalog No. ABIN6991740

Product Details anti-ATG2B Antibody

Target: ATG2B (Autophagy Related 2B (ATG2B))

Binding Specificity: AA 450-500, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG2B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: ATG2B antibody is predicted to not cross-react with other ATG2A.

Purification: ATG2B Antibody is affinity chromatography purified via peptide column.

Immunogen: ATG2B antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATG2B. The immunogen is located within amino acids 450 - 500 of ATG2B.

Isotype: IgG

Application Details

Application Notes: ATG2B antibody can be used for detection of ATG2B by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATG2B Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ATG2B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ATG2B

Target: ATG2B (Autophagy Related 2B (ATG2B))

Alternative Name: ATG2B (ATG2B Products)

Synonyms: C14orf103 antibody, 2410024A21Rik antibody, AI047755 antibody, AI503411 antibody, AW558123 antibody, C030004M05Rik antibody, C630028L02Rik antibody, mKIAA4067 antibody, autophagy related 2B antibody, ATG2B antibody, Atg2b antibody

Background: ATG2B Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.

Molecular Weight: 229 kDa

Gene ID: 55102

NCBI Accession: NP_060506

UniProt: Q96BY7