NDFIP1 antibody (N-Term)

Catalog No. ABIN6991731

Product Details anti-NDFIP1 Antibody

Target: NDFIP1 (Nedd4 Family Interacting Protein 1 (NDFIP1))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NDFIP1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: NDFIP1 antibody is predicted to not cross-react with NDFIP2.

Purification: NDFIP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: NDFIP1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human NDFIP1. The immunogen is located within the first 50 amino acids of NDFIP1.

Isotype: IgG

Application Details

Application Notes: NDFIP1 antibody can be used for detection of NDFIP1 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: NDFIP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: NDFIP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NDFIP1

Target: NDFIP1 (Nedd4 Family Interacting Protein 1 (NDFIP1))

Alternative Name: NDFIP1 (NDFIP1 Products)

Synonyms: zgc:55546 antibody, wu:fc17e11 antibody, n4wbp5 antibody, MGC108163 antibody, ndfip1 antibody, NDFIP1 antibody, N4WBP5 antibody, 0610010M22Rik antibody, N4wbp5 antibody, Nedd4 family interacting protein 1 antibody, Nedd4 WW domain-binding protein 5 antibody, ndfip1 antibody, NDFIP1 antibody, n4wbp5 antibody, Ndfip1 antibody

Background: NDFIP1 Antibody: The NEDD4 family-interacting protein 1 (NDFIP1) belongs to a small group of evolutionarily conserved proteins with three transmembrane domains and is an integral Golgi membrane protein. It is a potential target for ubiquitination by the Nedd4 family of proteins. NDFIP1 is strongly expressed in surviving neurons following acute cortical brain injury, and overexpression in cultured cortical neurons increased survival following growth factor starvation, suggesting that NDFIP1 may play a role in neuronal survival. NDFIP1 and the related protein NDFIP2 are thought to interact with and regulate multiple components of the EGF and PTEN/Akt signaling pathways. Recent studies suggest that NDFIP1 may also play a role in Th17 differentiation by limiting the production of proinflammatory cytokines.

Molecular Weight: 24 kDa

Gene ID: 80762

NCBI Accession: NP_085048

UniProt: Q9BT67

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Negative Regulation of Transporter Activity