KCP antibody (C-Term)

Catalog No. ABIN6991728

Product Details anti-KCP Antibody

Target: KCP (Kielin/Chordin-Like Protein (KCP))

Binding Specificity: AA 1320-1370, C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: At least two isoforms of CRIM2 are known to exist, this antibody will only detect the larger isoform. CRIM2 antibody is predicted to not cross-react with CRIM1.

Purification: CRIM2 Antibody is affinity chromatography purified via peptide column.

Immunogen: CRIM2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human CRIM2. The immunogen is located within amino acids 1320 - 1370 of CRIM2.

Isotype: IgG

Application Details

Application Notes: CRIM2 antibody can be used for detection of CRIM2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CRIM2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CRIM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for KCP

Target: KCP (Kielin/Chordin-Like Protein (KCP))

Alternative Name: CRIM2 (KCP Products)

Synonyms: CRIM2 antibody, KCP1 antibody, NET67 antibody, AW060220 antibody, CRIM-2 antibody, Crim2 antibody, Gm793 antibody, KCP-1 antibody, RGD1561119 antibody, crim2 antibody, kielin/chordin-like protein antibody, kielin/chordin-like protein L homeolog antibody, KCP antibody, LOC515624 antibody, Kcp antibody, kcp.L antibody

Background: CRIM2 Antibody: CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-β,1, suppressing activin- and TGF-β,1-dependent transcription.

Gene ID: 375616

NCBI Accession: NP_001129386

UniProt: Q6ZWJ8