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SIGLEC15 antibody (N-Term)

SIGLEC15 Reactivity: Human, Mouse, Rat ELISA, WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991662
  • Target See all SIGLEC15 Antibodies
    SIGLEC15 (Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15))
    Binding Specificity
    • 7
    • 6
    • 6
    • 2
    • 1
    AA 50-100, N-Term
    Reactivity
    • 25
    • 10
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 23
    • 2
    Rabbit
    Clonality
    • 23
    • 2
    Polyclonal
    Conjugate
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIGLEC15 antibody is un-conjugated
    Application
    • 15
    • 12
    • 10
    • 2
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    SIGLEC15 antibody is predicted to not cross-react with other SIGLEC family members.
    Purification
    SIGLEC15 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    SIGLEC15 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SIGLEC15. The immunogen is located within amino acids 50 - 100 of SIGLEC15.
    Isotype
    IgG
    Top Product
    Discover our top product SIGLEC15 Primary Antibody
  • Application Notes
    SIGLEC15 antibody can be used for detection of SIGLEC15 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    SIGLEC15 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    SIGLEC15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SIGLEC15 (Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15))
    Alternative Name
    SIGLEC15 (SIGLEC15 Products)
    Synonyms
    RGD1565948 antibody, CD33L3 antibody, HsT1361 antibody, SIGLEC-15 antibody, Cd33l3 antibody, EG620235 antibody, SIGLEC-I antibody, sialic acid binding Ig-like lectin 15 antibody, sialic acid binding Ig like lectin 15 antibody, Siglec15 antibody, SIGLEC15 antibody
    Background
    SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.
    Molecular Weight
    Predicted: 36 kDa

    Observed: 42 kDa
    Gene ID
    284266
    NCBI Accession
    NP_998767
    UniProt
    Q6ZMC9
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