SIVA1 antibody (N-Term)

Catalog No. ABIN6991621

Product Details anti-SIVA1 Antibody

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Chicken

Clonality: Polyclonal

Conjugate: This SIVA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: SIVA Antibody is affinity chromatography purified via peptide column.

Immunogen: SIVA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SIVA. The immunogen is located within the first 50 amino acids of SIVA.

Isotype: IgY

Application Details

Application Notes: SIVA antibody can be used for detection of EPAC1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SIVA Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SIVA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SIVA1

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Alternative Name: SIVA (SIVA1 Products)

Synonyms: CD27BP antibody, SIVA antibody, Siva-1 antibody, Siva-2 antibody, CD27bp antibody, Siva antibody, SIVA1 apoptosis inducing factor antibody, SIVA1, apoptosis-inducing factor antibody, SIVA1 antibody, Siva1 antibody

Background: SIVA Antibody: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ,-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.

Gene ID: 10572

NCBI Accession: NP_068355

UniProt: O15304

Pathways: Positive Regulation of Endopeptidase Activity