LEMD3 antibody (C-Term)

Catalog No. ABIN6991613

Product Details anti-LEMD3 Antibody

Target: LEMD3 (LEM Domain Containing 3 (LEMD3))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LEMD3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: At least three isoforms of LEMD3 are known to exist, this antibody will detect all isoforms. LEMD3 antibody is predicted to not cross-react with LEMD1 and LEMD2

Purification: LEMD3 Antibody is affinity chromatography purified via peptide column.

Immunogen: LEMD3 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LEMD3. The immunogen is located within the last 50 amino acids of LEMD3.

Isotype: IgG

Application Details

Application Notes: LEMD3 antibody can be used for detection of LEMD3 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LEMD3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LEMD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for LEMD3

Target: LEMD3 (LEM Domain Containing 3 (LEMD3))

Alternative Name: LEMD3 (LEMD3 Products)

Synonyms: MAN1 antibody, AI316861 antibody, Man1 antibody, im:7158446 antibody, wu:fb34b12 antibody, si:dkey-6a5.6 antibody, RGD1561001 antibody, man1 antibody, sane antibody, xman1 antibody, lemd3 antibody, LEM domain containing 3 antibody, LEM domain containing 3 S homeolog antibody, LEMD3 antibody, Lemd3 antibody, lemd3 antibody, lemd3.S antibody

Background: LEMD3 Antibody: LEMD3 (LEM domain-containing 3) is a lem-domain containing protein, also known as MAN1, whose loss of function results in disorders characterized by osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. LEMD3 is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells.

Gene ID: 23592

NCBI Accession: NP_055134

UniProt: Q9Y2U8