CCDC141 antibody (N-Term)

Catalog No. ABIN6991553

Product Details anti-CCDC141 Antibody

Target: CCDC141 (Coiled-Coil Domain Containing 141 (CCDC141))

Binding Specificity: AA 40-90, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC141 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: At least four isoforms of CCDC141 are known to exist.

Purification: CCDC141 Antibody is affinity chromatography purified via peptide column.

Immunogen: CCDC141 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC141. The immunogen is located within amino acids 40 - 90 of CCDC141.

Isotype: IgG

Application Details

Application Notes: CCDC141 antibody can be used for detection of CCDC141 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CCDC141 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CCDC141 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CCDC141

Target: CCDC141 (Coiled-Coil Domain Containing 141 (CCDC141))

Alternative Name: CCDC141 (CCDC141 Products)

Synonyms: CAMDI antibody, 2610301F02Rik antibody, ENSMUSG00000075261 antibody, coiled-coil domain containing 141 antibody, CCDC141 antibody, Ccdc141 antibody

Background: CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.

Gene ID: 285025

NCBI Accession: NP_775919

UniProt: Q6ZP82