WDR35 antibody (N-Term)

Catalog No. ABIN6991385

Product Details anti-WDR35 Antibody

Target: WDR35 (WD Repeat Domain 35 (WDR35))

Binding Specificity: AA 60-110, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR35 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: WDR35 antibody is human specific.

Purification: WDR35 Antibody is affinity chromatography purified via peptide column.

Immunogen: WDR35 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human WDR35. The immunogen is located within amino acids 60 - 110 of WDR35.

Isotype: IgG

Application Details

Application Notes: WDR35 antibody can be used for detection of WDR35 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: WDR35 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: WDR35 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for WDR35

Target: WDR35 (WD Repeat Domain 35 (WDR35))

Alternative Name: WDR35 (WDR35 Products)

Synonyms: 4930459M12Rik antibody, 4931430C06 antibody, mKIAA1336 antibody, RGD1564116 antibody, Wdr35 antibody, CED2 antibody, IFT121 antibody, im:7159945 antibody, si:ch211-206k20.4 antibody, WD repeat domain 35 antibody, Wdr35 antibody, WDR35 antibody, wdr35 antibody

Background: WDR35 Antibody: WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.

Gene ID: 57539

NCBI Accession: NP_001006658

UniProt: Q9P2L0

Pathways: Hedgehog Signaling