TMEM184C antibody (C-Term)

Catalog No. ABIN6991312

Product Details anti-TMEM184C Antibody

Target: TMEM184C (Transmembrane Protein 184C (TMEM184C))

Binding Specificity: AA 340-390, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM184C antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: TMEM184C Antibody is affinity chromatography purified via peptide column.

Immunogen: TMEM184C antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TMEM184C. The immunogen is located within amino acids 340 - 390 of TMEM184C.

Isotype: IgG

Application Details

Application Notes: TMEM184C antibody can be used for detection of TMEM184C by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TMEM184C Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TMEM184C antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TMEM184C

Target: TMEM184C (Transmembrane Protein 184C (TMEM184C))

Alternative Name: TMEM184C (TMEM184C Products)

Synonyms: TMEM34 antibody, 8430433H16Rik antibody, AI645453 antibody, AL033298 antibody, BC004056 antibody, Tmem34 antibody, transmembrane protein 184C antibody, transmembrane protein 184C L homeolog antibody, TMEM184C antibody, Tmem184c antibody, tmem184c.L antibody

Background: TMEM184C Antibody: Anaplastic thyroid cancer is one of the most lethal forms of cancer, but the precise carcinogenic mechanism has not been identified. TMEM184C, also known as TMEM34, was identified in a cDNA microarray analysis as being down-regulated in anaplastic thyroid cancers compared to normal thyroid tissues. TMEM184C protein expression was also lower in cell lines derived from these types of cancers compared to that of normal thyroid tissues or cell lines based on other types of thyroid cancers. Furthermore, transfection of TMEM34 into KTA2 cells led to the inhibition of cell growth, suggesting that TMEM184C might act as a tumor suppressor in anaplastic thyroid cancers.

Gene ID: 55751

NCBI Accession: NP_060711

UniProt: Q9NVA4