Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

BCAS2 antibody (C-Term)

BCAS2 Reactivity: Human, Mouse, Rat WB, ELISA, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991284
  • Target See all BCAS2 Antibodies
    BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))
    Binding Specificity
    • 11
    • 8
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 40
    • 15
    • 13
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 41
    • 2
    Rabbit
    Clonality
    • 42
    • 1
    Polyclonal
    Conjugate
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BCAS2 antibody is un-conjugated
    Application
    • 33
    • 20
    • 5
    • 5
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    BCAS2 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    BCAS2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human BCAS2. The immunogen is located within the last 50 amino acids of BCAS2.
    Isotype
    IgG
    Top Product
    Discover our top product BCAS2 Primary Antibody
  • Application Notes
    BCAS2 antibody can be used for detection of BCAS2 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    BCAS2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    BCAS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))
    Alternative Name
    BCAS2 (BCAS2 Products)
    Synonyms
    DAM1 antibody, SPF27 antibody, Snt309 antibody, 6430539P16Rik antibody, AI132645 antibody, C76366 antibody, C80030 antibody, BCAS2 antibody, cb302 antibody, zgc:101730 antibody, BCAS2, pre-mRNA processing factor antibody, breast carcinoma amplified sequence 2 antibody, breast carcinoma amplified sequence 2 L homeolog antibody, BCAS2 antibody, Bcas2 antibody, bcas2 antibody, bcas2.L antibody, CpipJ_CPIJ003889 antibody
    Background
    BCAS2 Antibody: BCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines. The chromosomal region containing this gene, 1p13.3021, is amplified in these cells lines. BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression, and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage. Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells, but causes G2-M arrest in p53-null or -mutant cells, this effect was reversed with the expression of ectopic BCAS2. BCAS2 may thus be potentially useful as a therapeutic target in the treatment of cancer.
    Gene ID
    10286
    UniProt
    O75934
You are here:
Support