KCNK18 antibody (AA 210-260)

Catalog No. ABIN6991251

Product Details anti-KCNK18 Antibody

Target: KCNK18 (Potassium Channel Subfamily K Member 18 (KCNK18))

Binding Specificity: AA 210-260

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNK18 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: TRESK Antibody is affinity chromatography purified via peptide column.

Immunogen: TRESK antibody was raised against a 17 amino acid synthetic peptide from near the center of human TRESK. The immunogen is located within amino acids 210 - 260 of TRESK.

Isotype: IgG

Application Details

Application Notes: TRESK antibody can be used for detection of TRESK by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TRESK Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TRESK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for KCNK18

Target: KCNK18 (Potassium Channel Subfamily K Member 18 (KCNK18))

Alternative Name: TRESK (KCNK18 Products)

Synonyms: K2p18.1 antibody, MGR13 antibody, TRESK antibody, TRESK-2 antibody, TRESK2 antibody, TRIK antibody, Gm781 antibody, Tresk antibody, Tresk-2 antibody, Trik antibody, potassium two pore domain channel subfamily K member 18 antibody, potassium channel, subfamily K, member 18 antibody, KCNK18 antibody, Kcnk18 antibody

Background: TRESK Antibody: TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.

Gene ID: 338567

NCBI Accession: NP_862823

UniProt: Q7Z418