CENPO antibody (AA 170-220)

Catalog No. ABIN6991201

Product Details anti-CENPO Antibody

Target: CENPO (Centromere Protein O (CENPO))

Binding Specificity: AA 170-220

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CENPO antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: CENPO Antibody is affinity chromatography purified via peptide column.

Immunogen: CENPO antibody was raised against a 16 amino acid synthetic peptide from near the center of human CENPO. The immunogen is located within amino acids 170 - 220 of CENPO.

Isotype: IgG

Application Details

Application Notes: CENPO antibody can be used for detection of CENPO by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CENPO Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CENPO antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CENPO

Target: CENPO (Centromere Protein O (CENPO))

Alternative Name: CENPO (CENPO Products)

Synonyms: cenpo antibody, MGC144960 antibody, CENPO antibody, MAJ23.70 antibody, MAJ23_70 antibody, zgc:171667 antibody, CENP-O antibody, ICEN-36 antibody, MCM21R antibody, 2810429O05Rik antibody, 8430427C03Rik antibody, D12Ertd482e antibody, centromere protein O antibody, cenpo antibody, CENPO antibody, AT5G10710 antibody, Cenpo antibody

Background: CENPO Antibody: Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.

Gene ID: 79172

NCBI Accession: NP_077298

UniProt: Q9BU64