RWDD3 antibody (N-Term)

Catalog No. ABIN6991194

Product Details anti-RWDD3 Antibody

Target: RWDD3 (RWD Domain Containing 3 (RWDD3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RWDD3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: RWDD3 Antibody is affinity chromatography purified via peptide column.

Immunogen: RWDD3 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human RWDD3. The immunogen is located within the first 50 amino acids of RWDD3.

Isotype: IgG

Application Details

Application Notes: RWDD3 antibody can be used for detection of RWDD3 by Western blot at 0.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: RWDD3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: RWDD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RWDD3

Target: RWDD3 (RWD Domain Containing 3 (RWDD3))

Alternative Name: RWDD3 (RWDD3 Products)

Synonyms: DKFZp469N1913 antibody, RSUME antibody, 2510027J23Rik antibody, 3110037C01Rik antibody, AI035684 antibody, AI662458 antibody, X2CR1 antibody, X2cr1 antibody, zgc:73229 antibody, RWD domain containing 3 antibody, RWDD3 antibody, rwdd3 antibody, Rwdd3 antibody

Background: RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Iκ,Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-α,-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Iκ,Beta increased stability. RSUME-enhanced sumoylation of Iκ,Beta leads to the inhibition of NF-κ,Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

Gene ID: 25950

NCBI Accession: NP_056300

UniProt: Q9Y3V2