PERP antibody (C-Term)

Catalog No. ABIN6991120

Product Details anti-PERP Antibody

Target: PERP (TP53 Apoptosis Effector (PERP))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PERP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: PERP Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-PERP antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human PERP. The immunogen is located within the last 50 amino acids of PERP.

Isotype: IgG

Application Details

Application Notes: WB: 1-2 μ,g/mL, ICC: 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PERP Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PERP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PERP

Target: PERP (TP53 Apoptosis Effector (PERP))

Alternative Name: PERP (PERP Products)

Synonyms: KCP1 antibody, KRTCAP1 antibody, PIGPC1 antibody, RP3-496H19.1 antibody, THW antibody, dJ496H19.1 antibody, 1110017A08Rik antibody, kcp1 antibody, krtcap1 antibody, pigpc1 antibody, thw antibody, fk24g11 antibody, wu:fk24g11 antibody, PERP antibody, PERP, TP53 apoptosis effector antibody, PERP, TP53 apoptosis effector S homeolog antibody, PERP antibody, Perp antibody, perp.S antibody, perp antibody

Background: PERP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.

Molecular Weight: Predicted: 21kD

Observed: 21 kD kDa

Gene ID: 64058

NCBI Accession: NP_071404

UniProt: Q9JK95

Pathways: Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity