PCDH18 antibody (N-Term)

Catalog No. ABIN6991083

Product Details anti-PCDH18 Antibody

Target: PCDH18 (Protocadherin 18 (PCDH18))

Binding Specificity: AA 50-100, N-Term

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDH18 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: At least three isoforms of PCDH18 are known to exist. This antibody is predicted to not cross-react with PCDH12.

Purification: PCDH18 Antibody is affinity chromatography purified via peptide column.

Immunogen: PCDH18 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human PCDH18. The immunogen is located within amino acids 50 - 100 of PCDH18.

Isotype: IgG

Application Details

Application Notes: PCDH18 antibody can be used for detection of PCDH18 by Western blot at 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PCDH18 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PCDH18 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PCDH18

Target: PCDH18 (Protocadherin 18 (PCDH18))

Alternative Name: PCDH18 (PCDH18 Products)

Background: PCDH18 Antibody: Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 18 (PCDH18) was initially identified through screening of human and mouse ESTs using conserved cytoplasmic domain motifs. Tissue screening revealed PCDH18 broad expression in tissues such as brain, liver, heart, kidney, lung, and trachea. PCDH18 expression is also temporally and spatially regulated in the mouse embryonic brain and interacts with Disabled-1, an intracellular adapter protein involved in neuronal migration and cell positioning during mammalian brain development. PCDH18 was also found to be expressed in the developing zebrafish neural tube and central nervous system, lending support to the hypothesis that PCDH18 may play a role during brain development.

Gene ID: 54510

NCBI Accession: NP_061908

UniProt: Q9HCL0