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Junctophilin 1 antibody (C-Term)

JPH1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991017
  • Target See all Junctophilin 1 (JPH1) Antibodies
    Junctophilin 1 (JPH1)
    Binding Specificity
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 470-520, C-Term
    Reactivity
    • 15
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 12
    • 3
    Rabbit
    Clonality
    • 13
    • 2
    Polyclonal
    Conjugate
    • 11
    • 2
    • 1
    • 1
    This Junctophilin 1 antibody is un-conjugated
    Application
    • 10
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    JPH1 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    JPH1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human JPH1. The immunogen is located within amino acids 470 - 520 of JPH1.
    Isotype
    IgG
    Top Product
    Discover our top product JPH1 Primary Antibody
  • Application Notes
    JPH1 antibody can be used for detection of JPH1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    JPH1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    JPH1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    Junctophilin 1 (JPH1)
    Alternative Name
    JPH1 (JPH1 Products)
    Synonyms
    JP-1 antibody, JP1 antibody, ENSMUSG00000054314 antibody, Jp1 antibody, bZ1M12.3 antibody, jph1 antibody, si:rp71-1m12.3 antibody, Jph1 antibody, junctophilin 1 antibody, junctophilin 1a antibody, junctophilin-1 antibody, JPH1 antibody, Jph1 antibody, jph1 antibody, jph1a antibody, LOC100547979 antibody
    Background
    JPH1 Antibody: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH1 is essential for stabilizing the T-tubule and SR membranes to form junctions and provide an environment for the assembly of receptors such as the ryanodine receptor type 1 (RyR1).
    Gene ID
    56704
    UniProt
    Q9HDC5
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