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CNOT4 antibody (N-Term)

CNOT4 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990985
  • Target See all CNOT4 Antibodies
    CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))
    Binding Specificity
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 70-120, N-Term
    Reactivity
    • 44
    • 20
    • 12
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 33
    • 11
    Rabbit
    Clonality
    • 33
    • 11
    Polyclonal
    Conjugate
    • 27
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CNOT4 antibody is un-conjugated
    Application
    • 36
    • 21
    • 11
    • 5
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA
    Purification
    CNOT4 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    CNOT4 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CNOT4. The immunogen is located within amino acids 70 - 120 of CNOT4.
    Isotype
    IgG
    Top Product
    Discover our top product CNOT4 Primary Antibody
  • Application Notes
    CNOT4 antibody can be used for detection of CNOT4 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    CNOT4 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    CNOT4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))
    Alternative Name
    CNOT4 (CNOT4 Products)
    Synonyms
    CLONE243 antibody, NOT4 antibody, NOT4H antibody, Not4 antibody, Not4h antibody, Not4hp antibody, CNOT4 antibody, CCR4-NOT transcription complex subunit 4 antibody, RNA binding (RRM/RBD/RNP motifs) family protein antibody, CCR4-NOT transcription complex, subunit 4 antibody, CCR4-NOT transcription complex subunit 4 L homeolog antibody, CCR4-NOT transcription complex, subunit 4b antibody, CNOT4 antibody, AT3G45630 antibody, Cnot4 antibody, cnot4.L antibody, cnot4b antibody
    Background
    CNOT4 Antibody: CNOT4 is a component of the CCR4-NOT transcription complex, a complex that is implicated in the repression of RNA polymerase II transcription. In the CCR4-NOT complex, CNOT4 acts as an E3 ubiquitin-protein ligase and interacts with a subset of E2 ubiquitin-conjugating enzymes through a unique C4C4 RING domain. This E3 ligase activity was shown to be dependent on the selective and specific interaction with the ubiquitin conjugating enzyme UbcH5B. In yeast, mutations in CNOT4 that prevented its interaction with the UbcH5B homolog UBC4 caused increased sensitivity to hydroxyurea, heat shock, and hygromycin B, suggesting that CNOT4 and UbcH5B are involved in stress response in vivo. Multiple isoforms of CNOT4 are known to exist.
    Gene ID
    4850
    NCBI Accession
    NP_037448
    UniProt
    O95628
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