BICD1 antibody (C-Term)

Catalog No. ABIN6990932

Product Details anti-BICD1 Antibody

Target: BICD1 (Bicaudal D Homolog 1 (BICD1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BICD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: At least two isoforms of BICD1 are known to exist, this antibody will only recognize the larger isoform.

Purification: BICD1 Antibody is affinity chromatography purified via peptide column.

Immunogen: BICD1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human BICD1. The immunogen is located within the last 50 amino acids of BICD1.

Isotype: IgG

Application Details

Application Notes: BICD1 antibody can be used for detection of BICD1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: BICD1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: BICD1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BICD1

Target: BICD1 (Bicaudal D Homolog 1 (BICD1))

Alternative Name: BICD1 (BICD1 Products)

Synonyms: BICD antibody, B830009D06Rik antibody, mKIAA4125 antibody, bicaudal D homolog 1 L homeolog antibody, BICD cargo adaptor 1 antibody, bicaudal D homolog 1 (Drosophila) antibody, bicd1.L antibody, BICD1 antibody, Bicd1 antibody

Background: BICD1 Antibody: BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.

Gene ID: 636

NCBI Accession: NP_001705

UniProt: Q96G01

Pathways: Ribonucleoprotein Complex Subunit Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, Maintenance of Protein Location