UNC93B1 antibody (N-Term)

Catalog No. ABIN6990887

Product Details anti-UNC93B1 Antibody

Target: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Binding Specificity: AA 80-130, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC93B1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: Multiple isoforms of Unc93b are known to exist. This antibody will not cross-react with Unc93a.

Purification: Unc93b Antibody is affinity chromatography purified via peptide column.

Immunogen: Unc93b antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human Unc93b. The immunogen is located within amino acids 80 - 130 of Unc93b.

Isotype: IgG

Application Details

Application Notes: Unc93b antibody can be used for the detection of Unc93b by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Unc93b Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Unc93b antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for UNC93B1

Target: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Alternative Name: Unc93b (UNC93B1 Products)

Synonyms: UNC93 antibody, IIAE1 antibody, UNC93B antibody, Unc-93B1 antibody, Unc93b antibody, unc-93 homolog B1, TLR signaling regulator antibody, unc-93 homolog B1 (C. elegans) antibody, UNC93B1 antibody, Unc93b1 antibody

Background: Unc93b Antibody: The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9, the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.

Molecular Weight: 56, 66 kDa

Gene ID: 81622

UniProt: Q9H1C4

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades