TMC6 antibody (AA 560-610)

Catalog No. ABIN6990885

Product Details anti-TMC6 Antibody

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Binding Specificity: AA 560-610

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMC6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.

Purification: EVER1 Antibody is affinity chromatography purified via peptide column.

Immunogen: EVER1 antibody was raised against a 15 amino acid synthetic peptide from near the center of human EVER1. The immunogen is located within amino acids 560 - 610 of EVER1.

Isotype: IgG

Application Details

Application Notes: EVER1 antibody can be used for the detection of EVER1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: EVER1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: EVER1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TMC6

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Alternative Name: EVER1 (TMC6 Products)

Synonyms: EVER1 antibody, zgc:92610 antibody, MGC83549 antibody, ever1 antibody, EV1 antibody, EVIN1 antibody, LAK-4P antibody, D11Ertd204e antibody, transmembrane channel like 6 antibody, transmembrane channel-like 6b antibody, transmembrane channel like 6 L homeolog antibody, transmembrane channel-like gene family 6 antibody, TMC6 antibody, tmc6b antibody, tmc6.L antibody, tmc6 antibody, Tmc6 antibody

Background: EVER1 Antibody: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.

Gene ID: 11322

UniProt: Q7Z403