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FBXL20 antibody (N-Term)

FBXL20 Reactivity: Human, Mouse, Rat ELISA, WB, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990848
  • Target See all FBXL20 Antibodies
    FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))
    Binding Specificity
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 13
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 11
    • 2
    Rabbit
    Clonality
    • 11
    • 2
    Polyclonal
    Conjugate
    • 10
    • 1
    • 1
    • 1
    This FBXL20 antibody is un-conjugated
    Application
    • 8
    • 7
    • 3
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purification
    SCRAPPER Antibody is affinity chromatography purified via peptide column.
    Immunogen
    SCRAPPER antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of the human SCRAPPER. The immunogen is located within the first 50 amino acids of SCRAPPER.
    Isotype
    IgG
    Top Product
    Discover our top product FBXL20 Primary Antibody
  • Application Notes
    SCRAPPER antibody can be used for detection of SCRAPPER by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    SCRAPPER Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    SCRAPPER antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))
    Alternative Name
    SCRAPPER (FBXL20 Products)
    Synonyms
    Fbl2 antibody, Fbl20 antibody, fbl20 antibody, MGC81000 antibody, scrapper antibody, FBL2 antibody, 2610511F20Rik antibody, 4632423N09Rik antibody, AI849362 antibody, AL117906 antibody, C86145 antibody, Scr antibody, mKIAA4147 antibody, FBXL2 antibody, Fbxl2 antibody, F-box and leucine rich repeat protein 20 antibody, F-box and leucine-rich repeat protein 20 L homeolog antibody, F-box and leucine-rich repeat protein 20 antibody, F-box/LRR-repeat protein 20 antibody, putative fbxl20 antibody, F-box and leucine rich repeat protein 2 antibody, FBXL20 antibody, fbxl20.L antibody, LOAG_14232 antibody, LOC100080065 antibody, Smp_097020.1 antibody, FBXL2 antibody, Fbxl20 antibody
    Background
    SCRAPPER Antibody: Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
    Gene ID
    84961
    NCBI Accession
    NP_116264
    UniProt
    Q96IG2
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