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Cyclin O antibody (AA 90-140)

CCNO Reactivity: Human, Mouse, Rat ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990652
  • Target See all Cyclin O (CCNO) Antibodies
    Cyclin O (CCNO)
    Binding Specificity
    • 13
    • 9
    • 5
    • 1
    • 1
    AA 90-140
    Reactivity
    • 23
    • 4
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 23
    • 1
    Rabbit
    Clonality
    • 24
    Polyclonal
    Conjugate
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    This Cyclin O antibody is un-conjugated
    Application
    • 19
    • 17
    • 3
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Specificity
    At least two isoforms of Cyclin O are known to exist, this antibody will recognize both isoforms.
    Purification
    Cyclin O Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Cyclin O antibody was raised against a 13 amino acid synthetic peptide from near the center of human Cyclin O. The immunogen is located within amino acids 90 - 140 of Cyclin O.
    Isotype
    IgG
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    Discover our top product CCNO Primary Antibody
  • Application Notes
    Cyclin O antibody can be used for the detection of Cyclin O by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Cyclin O Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    Cyclin O antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    Cyclin O (CCNO)
    Alternative Name
    Cyclin O (CCNO Products)
    Synonyms
    RGD1565217 antibody, ccnu antibody, udg2 antibody, ung2 antibody, CCNU antibody, MGC131111 antibody, C86987 antibody, Ccnu antibody, E130318K11 antibody, Ung2 antibody, UDG2 antibody, cyclin O antibody, cyclin O L homeolog antibody, Ccno antibody, ccno antibody, CCNO antibody, ccno.L antibody
    Background
    Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this gene's product as a cyclin protein family member.
    Molecular Weight
    39 kDa
    Gene ID
    10309
    NCBI Accession
    NP_066970
    UniProt
    P22674
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