IL23 antibody (N-Term)

Catalog No. ABIN6990632

Product Details anti-IL23 Antibody

Target: IL23 (Interleukin 23 (IL23))

Binding Specificity: AA 40-90, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL23 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: IL-23 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-IL-23 antibody was raised against a peptide corresponding to 17 amino acids near the amino terminus of human IL-23. The immunogen is located within amino acids 40 - 90 of IL-23.

Isotype: IgG

Application Details

Application Notes: WB: 0.25-2 μ,g/mL, IF: 20 μ,g/mL, IHC: 2 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunofluorescence and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-23 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-23 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for IL23

Target: IL23 (Interleukin 23 (IL23))

Alternative Name: IL-23 (IL23 Products)

Synonyms: IL-23 antibody, p19 antibody, SGRF antibody, il23p19 antibody, interleukin 23, alpha subunit p19 antibody, interleukin 23 subunit alpha antibody, Il23a antibody, IL23A antibody

Background: IL-23 Antibody: Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α, from activated T cells, and can stimulate macrophages to produce TNF-α, and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

Molecular Weight: Predicted: 21kD

Observed: 22 kD kDa

Gene ID: 51561

UniProt: Q9NPF7