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CARD10 antibody (N-Term)

CARD10 Reactivity: Human ELISA, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990438
  • Target See all CARD10 Antibodies
    CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 33
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 33
    Rabbit
    Clonality
    • 33
    Polyclonal
    Conjugate
    • 16
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CARD10 antibody is un-conjugated
    Application
    • 23
    • 17
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    CARMA3 antibody is human specific. At least three isoforms of CARMA3 are known to exist, this antibody will only detect isoform 1. CARMA3 antibody is predicted not to cross-react with other CARMA proteins.
    Purification
    CARMA3 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    CARMA3 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CARMA3. The immunogen is located within the first 50 amino acids of CARMA3.
    Isotype
    IgG
    Top Product
    Discover our top product CARD10 Primary Antibody
  • Application Notes
    CARMA3 antibody can be used for detection of CARMA3 by immunohistochemistry at 5 μ,g/mL.

    Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    CARMA3 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    CARMA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))
    Alternative Name
    CARMA3 (CARD10 Products)
    Synonyms
    CARD10 antibody, BIMP1 antibody, CARMA3 antibody, AI449026 antibody, Bimp1 antibody, Carma3 antibody, caspase recruitment domain family, member 10 antibody, caspase recruitment domain family member 10 antibody, Card10 antibody, CARD10 antibody
    Background
    CARMA3 Antibody: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κ,B activation. When expressed in cells, this protein binds to BCL10 and activates NF-κ,B Recent experiments have shown that CARMA3 is required for EGF-induced NF-κ,B activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.
    Gene ID
    29775
    NCBI Accession
    NP_055365
    UniProt
    Q9BWT7
    Pathways
    S100 Proteins
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