Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

DR4 antibody (C-Term)

DR4 Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990419
  • Target See all DR4 Antibodies
    DR4 (Drought-Repressed 4 Protein (DR4))
    Binding Specificity
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 22
    • 9
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 15
    • 7
    Rabbit
    Clonality
    • 15
    • 7
    Polyclonal
    Conjugate
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DR4 antibody is un-conjugated
    Application
    • 11
    • 7
    • 5
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    DR4 antibody has no cross reaction to DR5
    Purification
    DR4 Antibody is Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Anti-DR4 antibody was raised against a peptide corresponding to 19 amino acids near the carboxy terminus of human DR4. The immunogen is located within the last 50 amino acids of DR4.
    Isotype
    IgG
    Top Product
    Discover our top product DR4 Primary Antibody
  • Application Notes
    WB: 1 μ,g/mL, IHC-P: 10 μ,g/mL, IHC: 10 μ,g/mL, IF: 20 μ,g/mL.

    Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples, Immunocytochemistry in human samples and Immunofluorescence in human and rat samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    DR4 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    DR4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    DR4 (Drought-Repressed 4 Protein (DR4))
    Alternative Name
    DR4 (DR4 Products)
    Synonyms
    APO2 antibody, CD261 antibody, DR4 antibody, TRAILR-1 antibody, TRAILR1 antibody, TNF receptor superfamily member 10a antibody, TNFRSF10A antibody
    Background
    DR4 Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL2, 3, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-κ,B activation in many tissues and cells.
    Molecular Weight
    Predicted: 50kD

    Observed: 55kD (Post-modification: 1 N-linked glycosylation) kDa
    Gene ID
    8797
    UniProt
    O00220
    Pathways
    Apoptosis, Positive Regulation of Endopeptidase Activity
You are here:
Support