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BMF antibody (C-Term)

BMF Reactivity: Human WB, ELISA, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990401
  • Target See all BMF Antibodies
    BMF (Bcl2 Modifying Factor (BMF))
    Binding Specificity
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 32
    • 14
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 27
    • 3
    • 3
    Rabbit
    Clonality
    • 27
    • 6
    Polyclonal
    Conjugate
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BMF antibody is un-conjugated
    Application
    • 25
    • 14
    • 10
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purification
    Bmf Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Bmf antibody was raised with a synthetic peptide corresponding to 14 amino acids near the carboxy terminus of human Bmf. The immunogen is located within the last 50 amino acids of Bmf.
    Isotype
    IgG
    Top Product
    Discover our top product BMF Primary Antibody
  • Application Notes
    Bmf antibody can be used for detection of Bmf by Western blot at 2.5 and 5 μ,g/mL. A band at approximately 25 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Bmf Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    Bmf antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    BMF (Bcl2 Modifying Factor (BMF))
    Alternative Name
    Bmf (BMF Products)
    Synonyms
    BMF antibody, AW260063 antibody, AW411872 antibody, Bcl2 modifying factor antibody, Bcl2 modifying factor L homeolog antibody, BCL2 modifying factor antibody, BMF antibody, bmf.L antibody, Bmf antibody
    Background
    Bmf Antibody: Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program. Bmf is constitutively expressed in many tissues.
    Molecular Weight
    25 kDa
    Gene ID
    90427
    NCBI Accession
    NP_277038
    UniProt
    Q96LC9
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