BCL2L13 antibody (AA 280-330)

Catalog No. ABIN6990398

Product Details anti-BCL2L13 Antibody

Target: BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))

Binding Specificity: AA 280-330

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2L13 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Bcl-rambo Antibody is affinity chromatography purified via peptide column.

Immunogen: Bcl-rambo antibody was raised against a 15 amino acid synthetic peptide from near the center of human Bcl-rambo. The immunogen is located within amino acids 280 - 330 of Bcl-rambo.

Isotype: IgG

Application Details

Application Notes: Bcl-rambo antibody can be used for the detection of Bcl-rambo by Western blot at 2 and 4 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Bcl-rambo Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Bcl-rambo antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BCL2L13

Target: BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))

Alternative Name: Bcl-rambo (BCL2L13 Products)

Synonyms: si:ch211-238n5.7 antibody, Mil1 antibody, BCL-RAMBO antibody, Bcl2-L-13 antibody, MIL1 antibody, E430016C20Rik antibody, Mil-1 antibody, BCL2 like 13 antibody, BCL2-like 13 (apoptosis facilitator) antibody, BCL2L13 antibody, bcl2l13 antibody, Bcl2l13 antibody

Background: Bcl-rambo Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.

Gene ID: 23786

UniProt: Q9BXK5

Pathways: Positive Regulation of Endopeptidase Activity