LRRC1 antibody (C-Term)

Catalog No. ABIN6990392

Product Details anti-LRRC1 Antibody

Target: LRRC1 (Leucine Rich Repeat Containing 1 (LRRC1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: Lano Antibody is affinity chromatography purified via peptide column.

Immunogen: Lano antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human Lano. The immunogen is located within the last 50 amino acids of Lano.

Isotype: IgG

Application Details

Application Notes: Lano antibody can be used for detection of Lano by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Lano Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Lano antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for LRRC1

Target: LRRC1 (Leucine Rich Repeat Containing 1 (LRRC1))

Alternative Name: Lano (LRRC1 Products)

Synonyms: LRRC1 antibody, LANO antibody, dJ523E19.1 antibody, A430093J20Rik antibody, AU016091 antibody, D030059I21 antibody, mKIAA4018 antibody, leucine rich repeat containing 1 antibody, Lrrc1 antibody, LRRC1 antibody

Background: Lano Antibody: Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble. The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells. Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions. It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues.

Molecular Weight: Predicted: 59 kDa

Observed: 59 kDa

Gene ID: 55227

UniProt: Q9BTT6