NKIRAS2 antibody (C-Term)

Catalog No. ABIN6990382

Product Details anti-NKIRAS2 Antibody

Target: NKIRAS2 (NFKB Inhibitor Interacting Ras-Like 2 (NKIRAS2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NKIRAS2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: KappaB ras2 Antibody is affinity chromatography purified via peptide column.

Immunogen: KappaB ras2 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human KappaB ras2. The immunogen is located within the last 50 amino acids of KappaB ras2.

Isotype: IgG

Application Details

Application Notes: KappaB ras2 antibody can be used for detection of KappaB ras1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KappaB ras2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KappaB ras2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NKIRAS2

Target: NKIRAS2 (NFKB Inhibitor Interacting Ras-Like 2 (NKIRAS2))

Alternative Name: KappaB ras2 (NKIRAS2 Products)

Background: KappaB ras2 Antibody: KappaB ras-1 (κ,B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Iκ,B (Iκ,B), an inhibitor of the transcription factor NF-κ,B. Iκ,B exists in two homologous forms, Iκ,B-alpha and Iκ,B-beta, although Iκ,B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Iκ,B-alpha-NF-κ,B complexes can shuttle in and out of the nucleus, Iκ,B-beta-NF-κ,B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Iκ,B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Iκ,B-beta and regulating the rate of degradation of Iκ,B-beta. This antibody is specific for kappaB-ras2 and has no cross-reactivity to kappaB-ras1.

Gene ID: 28511

NCBI Accession: NP_060065

UniProt: Q9NYR9