SARS-CoV-2 NSP14 antibody (AA 120-170)

Catalog No. ABIN6990150

Product Details anti-SARS-CoV-2 NSP14 Antibody

Target: SARS-CoV-2 NSP14 (ExoN) (SARS-CoV-2 Guanine-N7 Methyltransferase (NSP14) (ExoN))

Binding Specificity: AA 120-170

Reactivity: SARS Coronavirus-2 (SARS-CoV-2)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SARS-CoV-2 NSP14 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purification: SARS-CoV-2 (COVID-19) NSP14 (ExoN) Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-SARS-CoV-2 (COVID-19) NSP14 (ExoN) antibody was raised against a peptide corresponding to 14 amino acids near the center of SARS-CoV-2 (COVID-19) NSP14 (ExoN) protein. The immunogen is located between 120-170 amino acids of SARS-CoV-2 (COVID-19) NSP14 (ExoN).

Isotype: IgG

Application Details

Application Notes: IHC: 0.5 μ,g/mL .

Antibody validated: Immunohistochemistry in human samples. SARS-CoV-2 (COVID-19) NSP14 (ExoN) antibody can detect 2 ng of free peptide at 1 μ,g/mL in ELISA. All other applications and species not yet tested

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SARS-CoV-2 (COVID-19) NSP14 (ExoN) Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SARS-CoV-2 (COVID-19) NSP14 (ExoN) antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SARS-CoV-2 NSP14

Target: SARS-CoV-2 NSP14 (ExoN) (SARS-CoV-2 Guanine-N7 Methyltransferase (NSP14) (ExoN))

Alternative Name: SARS-CoV-2 Guanine-N7 Methyltransferase (NSP14) (ExoN Products)

Synonyms: pp1ab antibody, ORF1a polyprotein;ORF1ab polyprotein antibody, ORF1ab antibody

Target Type: Viral Protein

Background: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019-20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP14 (ExoN) is an enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity (3,4,5). It acts as a proofreading exoribonuclease for RNA replication, thereby lowering The sensitivity of the virus to RNA mutagens(6,7,8).

Gene ID: 43740578

NCBI Accession: YP_009725309

UniProt: P0DTC1