PAK1/2/3 antibody (pSer139, pSer141, pSer144)
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- Target See all PAK1/2/3 Antibodies
- PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
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Binding Specificity
- pSer139, pSer141, pSer144
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This PAK1/2/3 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS), Immunoprecipitation (IP)
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- Synthetic phospho-Peptide corresponding to residues surrounding Ser144 of human PAK1.
- Clone
- 7G3
- Isotype
- IgG
- Top Product
- Discover our top product PAK1/2/3 Primary Antibody
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- Application Notes
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IP(1-2 μg)
IHC() - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
- Alternative Name
- PAK1+PAK2+PAK3 (PAK1/2/3 Products)
- Synonyms
- X-PAK1 antibody, XPak1 antibody, pak antibody, pak-1 antibody, pakalpha antibody, p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog antibody, p21 (RAC1) activated kinase 1 antibody, pak1.S antibody, PAK1 antibody
- Background
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Synonyms: ,
Background: PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Gene ID
- 5063
- UniProt
- O75914
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