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ROCK1 antibody

ROCK1 Reactivity: Human, Mouse, Rat WB, IHC, IP, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6989875
  • Target See all ROCK1 Antibodies
    ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
    Reactivity
    • 79
    • 56
    • 54
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 72
    • 8
    Rabbit
    Clonality
    • 62
    • 18
    Polyclonal
    Conjugate
    • 33
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This ROCK1 antibody is un-conjugated
    Application
    • 62
    • 27
    • 26
    • 20
    • 16
    • 13
    • 10
    • 10
    • 9
    • 7
    • 6
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 400-660 of human ROCK1 (NP_005397.1).
    Isotype
    IgG
    Top Product
    Discover our top product ROCK1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IP(1-2 μg)
    IHC()
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
    Alternative Name
    ROCK1 (ROCK1 Products)
    Synonyms
    LOC100229794 antibody, CG9774 antibody, DROK antibody, DRhk antibody, DRok antibody, Dmel\\CG9774 antibody, Drok antibody, ROCK antibody, ROCK-1 antibody, ROCK1 antibody, ROK antibody, ROKalpha/beta antibody, Rhk antibody, RhoK antibody, Rock antibody, Rok antibody, dROK antibody, dRok antibody, drok antibody, 1110055K06Rik antibody, Rock-I antibody, P160Rock antibody, ROCK-I antibody, P160ROCK antibody, p160ROCK antibody, Rho associated coiled-coil containing protein kinase 1 antibody, Rho kinase antibody, Rho-associated coiled-coil containing protein kinase 1 antibody, Rho-associated, coiled-coil containing protein kinase 1 antibody, ROCK1 antibody, Rok antibody, Rock1 antibody, rock1 antibody
    Background

    Synonyms: ROCK1,P160ROCK,ROCK-I

    Background: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.

    Gene ID
    6093
    UniProt
    Q13464
    Pathways
    Microtubule Dynamics, WNT Signaling, M Phase, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling
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