EGLN1 antibody

Catalog No. ABIN6989779

Product Details anti-EGLN1 Antibody

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EGLN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-426 of human EGLN1 (NP_071334.1).

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()
IF()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for EGLN1

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Alternative Name: EGLN1 (EGLN1 Products)

Synonyms: EGLN1 antibody, egln2 antibody, phd2 antibody, zgc:92314 antibody, AI503754 antibody, C1orf12 antibody, HIF-PH2 antibody, HPH-2 antibody, Hif-p4h-2 antibody, ORF13 antibody, Phd2 antibody, SM-20 antibody, PHD-2 antibody, PHD2 antibody, ECYT3 antibody, HIFPH2 antibody, HPH2 antibody, SM20 antibody, ZMYND6 antibody, egl nine homolog 1 (C. elegans) antibody, egl-9 family hypoxia inducible factor 1 antibody, egl-9 family hypoxia-inducible factor 1 S homeolog antibody, egl-9 family hypoxia-inducible factor 1b antibody, egl-9 family hypoxia-inducible factor 1 antibody, EGLN1 antibody, egln1.S antibody, egln1b antibody, Egln1 antibody

Background:

Synonyms: EGLN1,C1orf12,ECYT3,HALAH,HIF-PH2,HIFPH2,HPH-2,HPH2,PHD2,SM20,ZMYND6

Background: The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Gene ID: 54583

UniProt: Q9GZT9

Pathways: cAMP Metabolic Process, Warburg Effect