CEND1 antibody

Catalog No. ABIN6989616

Product Details anti-CEND1 Antibody

Target: CEND1 (Cell Cycle Exit and Neuronal Differentiation 1 (CEND1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CEND1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Synthetic Peptide within N-terminal Human CEND1.

Clone: 1D12

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CEND1

Target: CEND1 (Cell Cycle Exit and Neuronal Differentiation 1 (CEND1))

Alternative Name: CEND1 (CEND1 Products)

Synonyms: BM88 antibody, 1500001H12Rik antibody, AI415214 antibody, C38 antibody, RGD1309401 antibody, cell cycle exit and neuronal differentiation 1 antibody, CEND1 antibody, Cend1 antibody

Background:

Synonyms: BM88 antibody, BM88 antigen antibody, Cell cycle exit and neuronal differentiation 1 antibody, Cell cycle exit and neuronal differentiation protein 1 antibody, FLJ90066 antibody, MGC34326 antibody

Background: BM88 is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.

Gene ID: 51286

UniProt: Q8N111