MCFD2 antibody (AA 1-100)

Catalog No. ABIN6989560

Product Details anti-MCFD2 Antibody

Target: MCFD2 (Multiple Coagulation Factor Deficiency 2 (MCFD2))

Binding Specificity: AA 1-100

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCFD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Cross-Reactivity: Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse MCFD2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MCFD2

Target: MCFD2 (Multiple Coagulation Factor Deficiency 2 (MCFD2))

Alternative Name: MCFD2 (MCFD2 Products)

Synonyms: hm:zeh1186 antibody, wu:fc23b10 antibody, wu:fd50d08 antibody, zgc:103713 antibody, zgc:109915 antibody, MCFD2 antibody, DKFZp469B098 antibody, F5F8D antibody, F5F8D2 antibody, LMAN1IP antibody, SDNSF antibody, 1810021C21Rik antibody, F5f8d antibody, Lman1ip antibody, Sdnsf antibody, multiple coagulation factor deficiency 2 antibody, multiple coagulation factor deficiency 2 L homeolog antibody, MCFD2 antibody, mcfd2 antibody, mcfd2.L antibody, Mcfd2 antibody

Background:

Synonyms: 1810021C21Rik, DKFZp686G21263, F5F8D, LMAN1IP, MCFD 2, Mcfd2, MCFD2_MOUSE, Multiple coagulation factor deficiency protein 2, Neural stem cell derived neuronal survival protein, Neural stem cell-derived neuronal survival protein, SDNSF.

Background: This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 (lectin mannose binding protein 1, also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D), a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]

Gene ID: 193813

UniProt: Q8K5B2