STK24 antibody (pThr178)

Catalog No. ABIN6989149

Product Details anti-STK24 Antibody

Target: STK24 (serine/threonine Kinase 24 (STK24))

Binding Specificity: pThr178

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STK24 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human MST3 around the phosphorylation site of Thr178

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for STK24

Target: STK24 (serine/threonine Kinase 24 (STK24))

Alternative Name: MST3 (STK24 Products)

Synonyms: MST3 antibody, MST3B antibody, STE20 antibody, STK3 antibody, 1810013H02Rik antibody, C76483 antibody, MST-3 antibody, Mst3 antibody, Mst3b antibody, RGD1561742 antibody, stk24 antibody, wu:fi29b08 antibody, zgc:66137 antibody, 0610042I06Rik antibody, MST antibody, Mst2 antibody, Ste20 antibody, mess1 antibody, zgc:163071 antibody, mst3 antibody, mst3b antibody, ste20 antibody, stk3 antibody, serine/threonine kinase 24 antibody, serine/threonine kinase 24b (STE20 homolog, yeast) antibody, serine/threonine-protein kinase 24 antibody, serine/threonine kinase 3 antibody, serine/threonine kinase 24a (STE20 homolog, yeast) antibody, serine/threonine kinase 24 L homeolog antibody, STK24 antibody, Stk24 antibody, stk24b antibody, ATEG_04314 antibody, ATEG_09179 antibody, UREG_03984 antibody, BDBG_07988 antibody, MCYG_07323 antibody, Stk3 antibody, stk24a antibody, stk24.L antibody

Background:

Synonyms: MST3 (phospho T178), p-MST3 (phospho T178), Kinase responsive to stress 1, KRS1, Mammalian STE20 like protein kinase 2, Mammalian sterile 20-like 2, Mess1, MST, MST-2, MST2, Mst3, Serine/threonine kinase 3 (STE20 homolog, yeast), Serine/threonine kinase 3 (Ste20, yeast homolog), Serine/threonine protein kinase 3, Serine/threonine protein kinase Krs1, STE20 like kinase MST2.

Background: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Gene ID: 8428

UniProt: Q9Y6E0