PRKAR2A antibody (AA 1-404)
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- Target See all PRKAR2A Antibodies
- PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))
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Binding Specificity
- AA 1-404
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PRKAR2A antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- KO-Validated
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-404 of human PRKAR2A (NP_004148.1).
- Isotype
- IgG
- Top Product
- Discover our top product PRKAR2A Primary Antibody
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))
- Alternative Name
- PRKAR2A (PRKAR2A Products)
- Synonyms
- PKR2 antibody, PRKAR2 antibody, prkar2a antibody, zgc:85886 antibody, PRKAR2A antibody, 1110061A24Rik antibody, AI317181 antibody, AI836829 antibody, RII(alpha) antibody, protein kinase cAMP-dependent type II regulatory subunit alpha antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha, B antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha antibody, protein kinase, cAMP dependent regulatory, type II alpha antibody, protein kinase cAMP-dependent type 2 regulatory subunit alpha antibody, PRKAR2A antibody, prkar2ab antibody, Prkar2a antibody
- Background
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Synonyms: PRKAR2A,PKR2,PRKAR2
Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
- Gene ID
- 5576
- UniProt
- P13861
- Pathways
- Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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