GIPC1 antibody (AA 171-270)

Catalog No. ABIN6989016

Product Details anti-GIPC1 Antibody

Target: GIPC1 (GIPC PDZ Domain Containing Family, Member 1 (GIPC1))

Binding Specificity: AA 171-270

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIPC1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GIPC1?

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for GIPC1

Target: GIPC1 (GIPC PDZ Domain Containing Family, Member 1 (GIPC1))

Alternative Name: GIPC1 (GIPC1 Products)

Background:

Synonyms: C19ORF3, Chromosome 19 open reading frame 3, GIPC, GLUT1 C terminal binding protein, GLUT1CBP, IGF 1 receptor interacting protein 1, IIP 1, IIP1, NIP, PDZ domain-containing protein GIPC1, Regulator of G protein signalling 19 interacting protein 1, RGS19 interacting protein 1, RGS19IP1, SEMCAP, SYNECTIIN, Tax interaction protein 2, TIP 2, GIPC1_HUMAN.

Background: GIPC, for GAIP interacting protein at the C terminus (also designated SEMCAP-1 or synectin), is a PDZ domain containing protein that interacts with RGS-GAIP, a GTPase-activating protein (GAP) for G(a i) subunits. GIPC was also identified as TIP-2, a protein that interacts with the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. PDZ domain-containing proteins are primarily localized to cell-cell junctions in epithelial cells and neurons where they coordinate the assembly of multiprotein complexes. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating clathrin-coated vesicular trafficking. GIPC also associates with membrane bound semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain.

Gene ID: 10755

UniProt: O14908

Pathways: Dicarboxylic Acid Transport