KDM4C antibody (AA 291-390)

Catalog No. ABIN6989007

Product Details anti-KDM4C Antibody

Target: KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))

Binding Specificity: AA 291-390

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM4C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GASC1/KDM4C

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for KDM4C

Target: KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))

Alternative Name: GASC1/KDM4C (KDM4C Products)

Background:

Synonyms: GASC 1 protein, GASC1 antibody Gene amplified in squamous cell carcinoma 1 protein, JHDM3C, JmjC domain containing histone demethylation protein 3C, Jumonji domain containing protein 2C, KDM4C_HUMAN.

Background: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Gene ID: 23081

UniProt: Q9H3R0

Pathways: Nuclear Hormone Receptor Binding, Warburg Effect