SMAD9 antibody (AA 351-450) (Biotin)

Catalog No. ABIN6983069

Product Details anti-SMAD9 Antibody (Biotin)

Target: SMAD9 (SMAD Family Member 9 (SMAD9))

Binding Specificity: AA 351-450

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD9 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SMAD8

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for SMAD9

Target: SMAD9 (SMAD Family Member 9 (SMAD9))

Alternative Name: SMAD8 (SMAD9 Products)

Synonyms: SMAD8 antibody, MADH6 antibody, MADH9 antibody, PPH2 antibody, SMAD8A antibody, SMAD8B antibody, Madh8 antibody, Madh9 antibody, Smad8 antibody, SMAD family member 9 antibody, SMAD9 antibody, smad9 antibody, Smad9 antibody

Background:

Synonyms: AI528653 , BSP 1 , BSP1 , DKFZp781C1895 , DKFZp781O1323 , Dwarfin A , Dwf A , DwfA , Dwfc , hSMAD1 , hSmad5 , JV 41 , JV4 1 , JV41 , JV5 1 , MAD (mothers against decapentaplegic, Drosophila) homolog 1 , MAD (mothers against decapentaplegic, Drosophila) homolog 9 , MAD homolog 1 , MAD homolog 9 , MAD homolog1 (mothers against decapentaplegic, Drosophila) ,

Background: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway

Gene ID: 142891

UniProt: Q96LT4