RAP1A antibody (AA 1-100) (Biotin)

Catalog No. ABIN6982932

Product Details anti-RAP1A Antibody (Biotin)

Target: RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))

Binding Specificity: AA 1-100

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAP1A antibody is conjugated to Biotin

Application: Western Blotting (WB)

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RAP1A

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for RAP1A

Target: RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))

Alternative Name: RAP1A (RAP1A Products)

Background:

Synonyms: C21KG, RAP1, G 22K, G-22K, GTP binding protein smg p21A, GTP-binding protein smg p21A, KREV 1, KREV-1, KREV1, OTTHUMP00000013741, RAP 1A, RAP1, RAP1A, RAP1A member of RAS oncogene family, RAP1A_HUMAN, Ras related protein Krev 1, Ras related protein Rap 1A, RAS related protein RAP1A, Ras-related protein Krev-1, Ras-related protein Rap-1A, SMGP21, rap1a, RAS-related protein-1a precursor, Rap1A-retro2, RAP1A, member of RAS oncogene family.

Background: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

Gene ID: 5906

UniProt: P62834

Pathways: TCR Signaling, Neurotrophin Signaling Pathway, Signaling of Hepatocyte Growth Factor Receptor