BTBD12 antibody (AA 171-270) (Biotin)

Catalog No. ABIN6982787

Product Details anti-BTBD12 Antibody (Biotin)

Target: BTBD12 (BTB (POZ) Domain Containing 12 (BTBD12))

Binding Specificity: AA 171-270

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTBD12 antibody is conjugated to Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SLX4/BTBD12

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for BTBD12

Target: BTBD12 (BTB (POZ) Domain Containing 12 (BTBD12))

Alternative Name: SLX4 (BTBD12 Products)

Synonyms: Btbd12 antibody, RGD1566009 antibody, BTBD12 antibody, FANCP antibody, MUS312 antibody, AI256635 antibody, AI426760 antibody, D16Bwg1016e antibody, SLX4 structure-specific endonuclease subunit antibody, SLX4 structure-specific endonuclease subunit homolog antibody, SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) antibody, Slx4 antibody, SLX4 antibody

Background:

Synonyms: BTB (POZ) domain containing 12, BTB/POZ domain-containing protein 12, BTBD12, FANCP, KIAA1784, KIAA1987, MUS312, SLX 4, slx4, SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae), SLX4_HUMAN, Structure-specific endonuclease subunit slx4.

Background: This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]

Gene ID: 84464

UniProt: Q8IY92

Pathways: DNA Damage Repair