IRS2 antibody (AA 461-560) (Biotin)

Catalog No. ABIN6982776

Product Details anti-IRS2 Antibody (Biotin)

Target: IRS2 (Insulin Receptor Substrate 2 (IRS2))

Binding Specificity: AA 461-560

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRS2 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IRS-2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for IRS2

Target: IRS2 (Insulin Receptor Substrate 2 (IRS2))

Alternative Name: IRS-2 (IRS2 Products)

Background:

Synonyms: Insulin Receptor Substrate 2, IRS 2, IRS-2, IRS2, IRS2_HUMAN.

Background: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

Gene ID: 8660

UniProt: Q9Y4H2

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process