Latrophilin 1 antibody (AA 201-300) (Biotin)

Catalog No. ABIN6982672

Product Details anti-Latrophilin 1 Antibody (Biotin)

Target: Latrophilin 1 (LPHN1)

Binding Specificity: AA 201-300

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Latrophilin 1 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LPHN1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Latrophilin 1

Target: Latrophilin 1 (LPHN1)

Alternative Name: LPHN1 (LPHN1 Products)

Synonyms: LPHN1 antibody, CIRL1 antibody, CL1 antibody, LEC2 antibody, 2900070I05Rik antibody, AI182398 antibody, CLIBA antibody, Lec2 antibody, mKIAA0821 antibody, CL1BA antibody, adhesion G protein-coupled receptor L1 antibody, ADGRL1 antibody, Adgrl1 antibody

Background:

Synonyms: Calcium independent alpha latrotoxin receptor 1, Calcium-independent alpha-latrotoxin receptor 1, CIRL-1, CIRL1, CL1, CLIBA, G protein-coupled receptor for alpha-Latrotoxin, KIAA0821, Latrophilin 1, Latrophilin-1, Latrophilin1, LEC2, Lectomedin 2, Lectomedin-2, LPHN 1, LPHN1, LPHN1_HUMAN.

Background: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Gene ID: 22859

UniProt: O94910

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis