TOPORS antibody (AA 21-120) (AbBy Fluor® 647)
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- Target See all TOPORS Antibodies
- TOPORS (Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS))
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Binding Specificity
- AA 21-120
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TOPORS antibody is conjugated to AbBy Fluor® 647
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Application
- Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human p53 BP3
- Isotype
- IgG
- Top Product
- Discover our top product TOPORS Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- TOPORS (Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS))
- Alternative Name
- p53 BP3 (TOPORS Products)
- Synonyms
- CG15104 antibody, Dmel\\CG15104 antibody, TOPORS antibody, dTopors antibody, dtopors antibody, fi75f04 antibody, wu:fi75f04 antibody, AW105885 antibody, LUN antibody, TP53BPL antibody, p53BP3/LUN antibody, P53BP3 antibody, RP31 antibody, Topoisomerase I-interacting protein antibody, TOP1 binding arginine/serine rich protein antibody, topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase antibody, topoisomerase I binding, arginine/serine-rich b antibody, topoisomerase I binding, arginine/serine-rich antibody, Topors antibody, TOPORS antibody, topors antibody, toporsb antibody
- Background
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Synonyms: AW105885, E3 ubiquitin protein ligase Topors, E3 ubiquitin-protein ligase Topors, LUN, p53 binding protein 3, p53 BP3/LUN, p53-binding protein 3, p53BP3, p53BP3/LUN, Retinitis pigmentosa 31, RP31, SUMO1 protein E3 ligase Topors, SUMO1-protein E3 ligase Topors, Topoisomerase I binding arginine/serine rich, Topoisomerase I binding arginine/serine rich protein, Topoisomerase I binding protein, Topoisomerase I binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding RS protein, TOPORS, TOPRS_HUMAN, TP53BPL, Tumor protein p53 binding protein, Tumor suppressor p53 binding protein 3, Tumor suppressor p53-binding protein 3.
Background: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
- Gene ID
- 10210
- UniProt
- Q9NS56
- Pathways
- Maintenance of Protein Location
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