KLHL18 antibody (AA 451-550) (AbBy Fluor® 488)

Catalog No. ABIN6977486

Product Details anti-KLHL18 Antibody (AbBy Fluor® 488)

Target: KLHL18 (Kelch-Like 18 (KLHL18))

Binding Specificity: AA 451-550

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLHL18 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KLHL18

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KLHL18

Target: KLHL18 (Kelch-Like 18 (KLHL18))

Alternative Name: KLHL18 (KLHL18 Products)

Synonyms: A930041K15 antibody, AW545966 antibody, kelch-like 18 antibody, kelch like family member 18 antibody, Klhl18 antibody, KLHL18 antibody

Background:

Synonyms: Kelch-like protein 18, KLHL18, KIAA0795, OK/SW-cl.74

Background: KLHL18 is a 574 amino acid protein that is related to the Drosophila kelch protein, which is required to maintain actin organization in ovarian ring canals. Mutations affecting Kelch function result in failure of Kelch to associate with the ring canals and subsequent female sterility. Human KLHL18 protein contains six kelch repeats, one BACK (BTB/Kelch associated) domain and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. There are two isoforms of KLHL18 that are produced as a result of alternative splicing events.

Gene ID: 23276

UniProt: O94889