NUDCD1 antibody (AA 431-530) (AbBy Fluor® 350)

Catalog No. ABIN6976831

Product Details anti-NUDCD1 Antibody (AbBy Fluor® 350)

Target: NUDCD1 (NudC Domain Containing 1 (NUDCD1))

Binding Specificity: AA 431-530

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUDCD1 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Horse,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NUDCD1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NUDCD1

Target: NUDCD1 (NudC Domain Containing 1 (NUDCD1))

Alternative Name: NUDCD1 (NUDCD1 Products)

Synonyms: Cml66 antibody, NUDCD1 antibody, CML66 antibody, OVA66 antibody, 4921532K09Rik antibody, AA407246 antibody, AW260430 antibody, AW556235 antibody, CML66-L antibody, RGD1310624 antibody, im:6901299 antibody, im:6912119 antibody, wu:fc11c02 antibody, zgc:110705 antibody, cml66 antibody, NudC domain containing 1 antibody, NudC domain-containing protein 1 antibody, NudC domain containing 1 S homeolog antibody, NUDCD1 antibody, nudcd1 antibody, CpipJ_CPIJ019282 antibody, nudc1 antibody, LOC777229 antibody, Nudcd1 antibody, nudcd1.S antibody

Background:

Synonyms: 4921532K09Rik, AA407246, AW260430, AW556235, Chronic myelogenous leukemia tumor antigen 66, CML66, CML66 L, FLJ14991, NudC domain containing 1, NudC domain-containing protein 1, NUDC1_HUMAN, nudcd1, OVA66, RGD1310624, Tumor antigen CML66.

Background: The NUDCD1 gene encodes the 583 amino acid CML66 protein which demonstrates expression in a variety of solid tumor cell lines and leukemias. Expression of CML66 in normal tissues is restricted to testis and heart. The CML66 antibody is found in sera of 18-38 % of patients with lung cancer, melanoma or prostate cancer. These findings indicate that CML66 may be immunogenic in a wide variety of malignancies and may be a target for antigen-specific immunotherapy. A short isoform of CML66, designated CML66-S, is a product of alternative splicing. CML66-S has the same C-terminus as full-lenghth CML66 (also designated CML66-L), but has a unique N-terminus. CML66-S shows predominant expression in testis, and is also expressed in very low levels in tumor cells, while CML66 is expressed in tumor cells and testis.

Gene ID: 84955

UniProt: Q96RS6